It's tough to establish what constitutes a regular harmful or lethal dose. Nevertheless, the lethal oral dose of codeine within an adult is claimed being in the array of 0.
Opioids are sought by drug abusers and those with habit Ailments and therefore are issue to prison diversion. Consider these hazards when prescribing or dispensing Promethazine HCl and Codeine Phosphate Oral Remedy. Methods to reduce these challenges contain prescribing the drug inside the smallest appropriate quantity and advising the client on the proper disposal of unused drug [see Client Counseling Information (17)].
Get health-related support right away if you have any quite really serious Unintended effects, which include: sluggish/shallow respiratory, seizures.
Tell your doctor In the event your cough will not improve in 5 days. Also, tell your doctor In case your affliction gets worse, or When you've got a headache that doesn't disappear, fever, or rash. These can be symptoms of a significant health care issue and should be checked by a physician.
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The diagnostic analysis of individuals using this syndrome is sophisticated. In arriving in a prognosis, it is necessary to determine conditions the place the medical presentation consists of both equally serious medical sickness (e.
The causal role of opioids within the clinical syndrome of hypogonadism is unfamiliar because the various healthcare, Actual physical, Life style, and psychological stressors that could impact gonadal hormone ranges haven't been adequately controlled for in scientific studies done up to now [see Adverse Reactions (6)].
Promethazine Carcinogenicity scientific tests have been executed with promethazine hydrochloride. Two-year scientific tests in F344/N rats and B6C3F1 mice ended up executed to assess the carcinogenic probable of promethazine hydrochloride. No proof of tumorigenicity was observed in male and female rats at promethazine hydrochloride oral doses as many as 33 mg/kg/day for five times/7 days (somewhere around comparable to ten instances the MRHD on a mg/m2 basis).
The combination of promethazine hydrochloride and codeine phosphate must be applied with caution in pediatric people 6 yrs and older (see Warnings-Use in Pediatric People).
Animal replica scientific studies haven't been done While using the drug mixture-promethazine and codeine. It is far from regarded whether or not this drug mix may cause fetal damage when administered to your pregnant woman or can have an effect on replica capacity.
Usually do not get any benzodiazepines or medicines that can cause drowsiness or sleepiness all through treatment method with Promethazine Hydrochloride and Codeine Phosphate Oral Answer. Check with your healthcare company for a summary of these medicines if You aren't absolutely sure.
Circumstances OF USE: The knowledge in this databases is intended to nutritional supplement, not substitute for, the abilities and judgment of Health care experts. The data is not intended to protect all attainable utilizes, directions, safeguards, drug interactions or adverse results, nor should it's construed to point that utilization of a selected drug is safe, appropriate or successful for yourself Promethazine codeine syrup or any person else.
Warning should be exercised when promethazine with codeine syrup is administered to the nursing lady.
INDICATIONS AND Use Promethazine HCl and Codeine Phosphate Oral Resolution is a combination of codeine, an opioid agonist; and promethazine, a phenothiazine, indicated to the momentary relief of cough and upper respiratory indications connected to allergy or maybe the frequent cold in people 18 years of age and older. (one)